How the brain's blood vessel network follows a three-stage blueprint from birth to adulthood

Researchers from the Paris Brain Institute and Sainte-Justine University Hospital in Montreal have, for the first time, ...
Frontiers

The Evolving Tumor-Immune Gene Mutations Interface: Novel Biomarkers for Response, Resistance, and Immunotherapeutic Strategies

The advent of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has revolutionized oncology. However, a significant proportion of patients ...
eLife

Gene specificity landscapes for comparative transcriptomic analysis across tissues, cell types, and species

This important study advances a new computational approach to measure and visualize gene expression specificity across different tissues and cell types. The framework is potentially helpful for ...
AlphaGalileo

Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications

As the “Method of the Year 2024”, spatial proteomics (SP) enables in situ characterization of protein localization, abundance ...
eLife

TAD boundaries and gene activity are uncoupled

Single-cell analysis fails to find a functional link between the organization of chromatin domain organization and gene activity.
Physician's Weekly

Roundtable: Understanding Juvenile Idiopathic Arthritis Through Synovial Tissue Atlas

Can a cellular atlas of juvenile idiopathic arthritis (JIA) synovium unlock more effective treatments for JIA?